Little Benjamin was subjected to an exhaustive schedule of tests in an attempt to explain the startling blue color. From a history of Perry County and some Fugate family Bibles listing ancestors, The blue people of troublesome creek has constructed a fairly complete story.
The enzyme eventually builds to normal levels in most children and to almost normal levels in those like Benjy, who carry one gene. Elizabeth Smith, apparently, was as pale-skinned as the mountain laurel that blooms every spring around the creek hollows.
Somebody with only one gene would not have the condition but could pass the gene to a child. Normally, people have less than about 1 percent of methemoglobin, a type of hemoglobin that is altered by being oxidized so is useless in carrying oxygen in the blood.
When Benjy was born with purple skin, his relatives told the perplexed doctors about his great grandmother Luna Fugate. Most of blue Fugates never suffered any health effects and lived into their 80s and 90s.
No mention of his skin color is made in the early histories of the area, but family lore has it that Martin himself was blue. Martin Fugate came to Troublesome Creek from France in and family folklore says he was blue.
Behlen II on seeing Luke Combs, a descendant of Fugate branch The blue people in Kentucky began to disappear in the early 20th century as families moved apart and the disease therefore became less common as inbreeding reduced, reported ABC News.
This information supplied by John Graves whose uncle was the father of the child. In other words, to get the disorder, a person would have to inherit two genes for it, one from each parent. No mention of his skin color is made in the early histories of the area, but family lore has it that Martin himself was blue.
Stacy counts Fugate blood in his own veins. Later in he was famous for another reason. When asked ahout it, he shakes his head and stares steadfastly ahead. His mother Hilda Stacy, 56, lives in Hazard, Kentucky. As coal trains and other modern highway connectors began connecting Troublesome Creek with the rest of the nation, people began leaving the area.
All them old fellers way back then was blue. I looked at other enzymes and nothing was wrong with them. In the case of acquired methemoglobinemia, the patient must be monitored for low blood oxygen levels and anemia since the amount of circulating normal hemoglobin may be reduced to extremely low levels.
All them old fellers way back then was blue. Hemoglobin is responsible for distributing oxygen to the body and without oxygen, the heart, brain and muscles can die. You could tell how much it bothered them to be blue. And they married the people who lived closest to them, the Combses, Smiths, Ritchies, and Stacys.
Stacy and they had 13 children. One of their sons, Levy, married a Ritchie girl and had eight children, one of these children was Luna. But Cawein knew from earlier studies that the body has an alternative method of converting methemoglobin back to normal.
Scott that was reported in the Journal of Clinical Investigation. Their son named Levy married into a nearby family and they had eight children. Normally diaphorase converts methemoglobin back to hemoglobin.
Cawein performed enzyme assays on additional blood samples from other blue family members.
Trudging up and down the hollows, fending off "the two mean dogs that everyone had in their front yard," the doctor and the nurse would spot someone at the top of a hill who looked blue and take off in wild pursuit. This information supplied by John Graves whose uncle was the father of the child.
One relative describes her as "blue all over," and another calls Luna "the bluest woman I ever saw. One of their sons, Levy, married a Ritchie girl and had eight children, one of them Luna. Somebody with only one gene would not have the condition but could pass the gene to a child.The Blue People Of Troublesome Creek.
34 likes. There coming to braid our ass hairs! Oh Nooo! Known as the blue people, the Fugates and others afflicted with the condition lived in the Kentucky hills of Troublesome and Balls Creek through the late s. THE BLUE PEOPLE OF TROUBLESOME CREEK The story of an Appalachian malady, an inquisitive doctor, and a paradoxical cure.
by Cathy Trost ©Science 82, November, The Fugate Family. Blue People Of Troublesome Creek, KY Names: Introduction: Hereditary methemoglobinemia (met-H) is a human genetic disease that is inherited as an autosomal recessive.
The gene is located on chromosome /5(5).
The Fugates, a family that lived in the hills of Kentucky, commonly known as the "Blue Fugates" or the Blue People of Kentucky, are notable for having been carriers of a genetic trait that led to the disease methemoglobinemia, which gives sufferers blue-tinged skin.
Dr. Cawein, of The Blue People of Troublesome Creek and Curing the Kentucky Blues, used methylene blue to repair the damaged hemoglobin.
That is, methylene blue, in its reduced form, is a colorless, water-solulble molecule.Download